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Liu PJ(1), Ye YX, Wang YX, Du JX, Pan YH, Fang XB. Author information: (1)Department of Oncological Radiotherapy, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China. oie464266@163.com. Each single miRNA of miR-92a family also yielded high diagnostic effectiveness with AUC of 0.90 [0.87–0.93] for miR-25, 0.94 [0.92–0.96] for miR-92a and 0.89 [0.82–0.95] for miR-363. In the subgroup analysis, multiple miRNAs had a higher diagnostic value compared to any single miRNA, which indicated that the combination of different miRNAs had higher diagnostic accuracy. Suppression of miR-92a-1-5p and restoration of FOXD1 may be a preventive approach for gastric IM in patients with bile regurgitation.

Mirna 92a

Role of MiRNA-92a in glioma 6613 S transition of the cell cycle following DNA dam - age by mediating the tumor suppressor gene p53 15. In colorectal cancer, KLF4 has been reported to 2017-11-22 · In this study, miRNA target prediction and experimental results identified KLF4 and Cezanne as direct targets for miR-92a and miR-486, respectively, which was consistent with findings reported 2015-10-13 · Thus, miR-92a-dependent p57 induction may contribute to butyrate’s anti-cancer effects. To examine the role of miR-92a in mediating butyrate’s anti-proliferative and pro-apoptotic actions, prior to butyrate exposure HCT116 cells were transfected with exogenous miR-92a or control miRNA (miR-C), the same treatment as Fig. 7b-e. 2021-02-01 · miRNA-92a controls blood vessel growth and angiogenesis . MRG-110 targets miR-92a to target blood vessel growth and to control ischemia. This molecule is in a phase-I clinical trial and is under development at miRagen therapeutics.

miR-18b overexpression identifies mantle cell lymphoma

In addition, correlation between miR-92a and cardiovascular disease was reported. miRNA inhibitors for miR-92a, miR-181a and microRNA inhibitor negative control (scrambled) oligonucleotides were purchased from Life Tech-nologies (Applied Biosystems, UK). For cell trans - fection, the HL-60 cells (2.5 × 105 cells) were cul-tivated in 6-well plate and after 24 hours reached PCa exosomes and the transferred miRNA, miR‐92a‐1‐5p, are critical mediators that disrupt bone homeostasis, degrade the bone matrix, induce pathological bone remodeling, and, ultimately, create an osteoclastic premetastatic niche for tumor growth. ACKNOWLEDGEMENTS.

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MicroRNA-92a mimics or inhibitor were transfected into the cells.

doi: 10.1136/gutjnl-2017-315318. 2018-06-07 MiRNA-92a promotes cell proliferation and invasion through binding to KLF4 in glioma. Eur Rev Med Pharmacol Sci Year: 2019 Vol. 23 - N. 15 Pages: 6612-6620 DOI: 10.26355/eurrev_201908_18550.
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miR-92a-3p - miRia - miRNA Immunoassays. Product filter. miR-92a-3p. Altered miRNA expression is found in most tumour types including CRC.14–18 Previously, we and others had reported that miR-21 and miR-92a exhibit enhanced expression in CRC tumour tissues compared with their adjacent normal tissues.19 20 We have also demonstrated that miR-92a was detectable at a higher level in plasma of patients with CRC.20 The use of stool-based miRNA markers for the miRNA-92a-3p is a single-stranded, non-coding RNA that has been reported to participate in regulating angiogenesis, inhibiting apoptosis, enhancing chondrocyte production, and inhibiting cartilage degradation.19, 20 Redell et al.18 reported that the expression level of miRNA-92a-3p increases significantly in the first 24 h after mild TBI injury but decreases in severe TBI patients. We suspect that the interactions between miR-92a and ΔSP1 may result from (i) possible G-U wobble base-pairings between the mutated nucleotides and miR-92a; and (ii) extensive base-pairing in the non-seed region of miR-92a (Fig.

Eur Rev Med Pharmacol Sci Year: 2019 Vol. 23 - N. 15 Pages: 6612-6620 DOI: 10.26355/eurrev_201908_18550. Keywords Related articles: LINC00467 promotes proliferation and invasion in glioma via interacting with miRNA … 2021-03-05 2017-11-22 2012-05-01 2015-10-13 We suspect that the interactions between miR-92a and ΔSP1 may result from (i) possible G-U wobble base-pairings between the mutated nucleotides and miR-92a; and (ii) extensive base-pairing in the non-seed region of miR-92a (Fig. 1), because the non-seed region of miRNAs (nucleotides 12–17) have been shown in mammalian cells to be important for miRNA targeting [22, 23]. You are here: Home Products and Services miRia - miRNA Immunoassays. miR-92a-3p - miRia - miRNA Immunoassays.
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diabetes mellitus is one of the most common metabolic diseases worldwide characterized by insulin resistance and pancreatic β cell dysfunction. miRNA plays an important role in DM. In previous studies, miRNA-92a could function as targets for innovative precision medicines to reduce T1D islet autoimmunity. The median serum levels of miR-92a, not miR-135, were significantly higher in SSc patients than normal subjects. The constitutive up-regulated miR-92a expression was also found in cultured dermal fibroblasts from SSc skin, which was decreased by the transfection with siRNA of TGF-β. The Different Roles of miRNA-92a-2-5p and let-7b-5p in Mitochondrial Translation in db/db Mice.

In addition, this study provides first evidence that local catheter-based delivery of the LNA-based miR-92a inhibitor more effectively augments the cardioprotective effects than systemic application.
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##gff-version 3 # microRNAs: MirGeneDB v2.0 # genome

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Postdoctoral position available to study the pathophysiology of

Gut . 2019 Oct;68(10):1751-1763.

Comments: Human miR-92a (previously named miR-92 here) has two predicted hairpin precursor sequences: mir-92a-1 on chromosome 13 (named mir-92-13 in [1]) and mir-92a-2 on chromosome X (named mir-92-X in [1]).miR-92a has also been cloned from mouse embryonic stem cells [2] and is predicted to be … 2017-07-15 miRNA microRNAs miR-92a microRNA-92a MPs microparticules oxLDL oxidized low-density lipoproteins SS shear stress. 436 Circulation Research January 31, 2014 the microarray data by qPCR (Figure 1B). First, miR-92a ex-pression was higher in HUVECs exposed to atheroprone low Original Article The Different Roles of miRNA-92a-2-5p and let-7b-5p in Mitochondrial Translation in db/db Mice Huaping Li, 1,2Beibei Dai, Jiahui Fan, 1,2 Chen Chen, Xiang Nie, Zhongwei Yin, Yanru Zhao, Xudong Zhang, and Dao Wen Wang1 1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key 2015-01-27 In the present study, we found that the upregulation of miRNA-92a-3p induced by TBI correlated with a decrease in integrin binding sialoprotein (IBSP) expression in callus formation. In vitro, overexpressing miRNA-92a-3p inhibited IBSP expression and accelerated osteoblast differentiation, whereas silencing of miRNA-92a-3p inhibited osteoblast activity. MicroRNA (miR)-17-92a expression plays a crucial role in lymphocyte ontogeny. We therefore set out to determine miR-92a expression levels in peripheral blood lymphocytes from healthy subjects to ascertain any association between these levels and ageing.